This enzyme includes two domains with distinct catalytic activities, a peptidylglycine alpha-hydroxylating monooxygenase PHM domain and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase PAL domain. PAM expression is increased in the secretory pathway of differentiated.
Peptide alpha-amidation is a widespread, often essential posttranslational modification shared by many bioactive peptides and accomplished by the products of a single gene encoding a multifunctional protein, peptidylglycine alpha-amidating monooxygenase PAM. PAM has two catalytic domains that work sequentially to produce the final alpha-amidated product peptide.
Peptidyl-glycine alpha-amidating monooxygenase is an enzyme that is required for the biosynthesis of many signaling peptides. This transformation is achieved by conversion of a prohormone to the corresponding amide C O NH 2.
Randall Deck, Corrille M. Donnelly, and Margaret A.
A variant lacking the transmembrane domain. Chemical compound and disease context of PAM 4-Phenylbutenoic acid PBA is an irreversible turnover-dependent inhibitor of PAM in vitro and has been shown to decrease lung cancer cell proliferation by inhibiting the synthesis of amidated growth factors .
Peptidylglycine alpha-amidating monooxygenase EC 1. By somatic cell hybridization, Ouafik et al.
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